Piportil L4: Full Drug Profile

Piportil L4 - General Information

Piportil L4 has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extra pyramidal reactions. It is used for the maintenance treatment of chronic non-agitated schizophrenic patients. Symptoms of overdose include severe extrapyramidal manifestations, hypotension, lethargy and sedation.

Pharmacology of Piportil L4

Piportil L4 has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extra pyramidal reactions.

Piportil L4 for patients

Piportil L4 Interactions

Piportil L4 Contraindications

Should not be administered in the presence of circulatory collapse, altered states of consciousness or comatose states, particularly when these are due to intoxication with central depressant drugs e.g., alcohol, hypnotics, narcotics. In severely depressed patients, in the presence of blood dyscrasias, liver disease, renal insufficiency, pheochromocytoma, or in patients with severe cardiovascular disorders or a history of hypersensitivity to phenothiazine derivatives.

It is not indicated for the management of psychoneurotic patients or geriatric patients with confusion and/or agitation.

As with other phenothiazines, pipotiazine is contraindicated in patients with suspected or established subcortical brain damage, with or without hypothalamic damage, since a hyperthermic reaction with temperatures above 40°C may occur, sometimes not until 14 to 16 hours after drug administration.

Phenothiazine compounds should not be used in patients receiving large doses of hypnotics, due to the possibility of potentiation.

Children:
The safety and efficacy of pipotiazine in children have not been established. Therefore, it is not indicated for use in children.

Additional information about Piportil L4

Piportil L4 Indication

For the maintenance treatment of chronic non-agitated schizophrenic patients.

Generic Name

Pipotiazine

Synonyms

Pipothiazine; Pipotiazina [inn-spanish]; Pipotiazinum [inn-latin]

Drug Category

Antipsychotic Agents

Drug Type

Small Molecule; Approved

Other Brand Names containing Pipotiazine

Piportil Depot; Piportil L4;

Toxicity (Overdose)

Symptoms of overdose include severe extrapyramidal manifestations, hypotension, lethargy and sedation.

Dosage Forms of Piportil L4

Solution Intramuscular

Chemical IUPAC Name

10-[3-[4-(2-hydroxyethyl)piperidin-1-yl]propyl]-N,N-dimethylphenothiazine-2-sulfonamide

Chemical Formula

C24H33N3O3S2

Organisms Affected

Humans and other mammals